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When Hagen was 11, her mother married Wolf Biermann, an anti-establishment singer-songwriter. Biermann's political views later influenced young Hagen.
Hagen left school at age sixteen, and went to Poland, where she began her career. After that, she returned to Germany and joined the cover band Fritzens Dampferband (Fritz's Steamboat Band), together with Achim Mentzel and others. She added songs by Janis Joplin and Tina Turner to the "allowable" set lists during shows.
From 1972 to 1973, Hagen enrolled in the crash-course performance program at The Central Studio for Light Music in East Berlin. Upon graduation, she formed the band Automobil.
In East Germany, she performed with the band Automobil, becoming one of the country's best-known young stars. Her most famous song from the early part of her career was Du hast den Farbfilm vergessen (You forgot the colour film), " a subtle dig mocking the sterile, gray, Communist state," in 1974. Her musical career in the GDR was cut short, however, when she and her mother left the country in 1976, following the expulsion of her stepfather.
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Back in Germany by mid-1977, Hagen formed the Nina Hagen Band in West Berlin's Kreuzberg district. In 1978 they released their self-titled debut album, which included the single "TV-Glotzer" (a cover of "White Punks on Dope" by The Tubes, though with entirely different German lyrics), and Auf'm Bahnhof Zoo, about West Berlin's then-notorious Berlin Zoologischer Garten station. The album also included a version of "Rangehn" ("Go For It"), a song she had previously recorded in East Germany, but with different music.
A European tour with a new band in 1980 was cancelled, and Hagen turned to the United States. A limited-edition 10-inch EP was released on vinyl that summer in the U.S. Two songs from her first album Nina Hagen Band were on the A side, and two songs from her second album Unbehagen were on the B-side. All four songs were sung in German, although two had English titles and the other two were covers of English-language songs with new German lyrics.
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In 1983, she released the album Angstlos and a minor European tour. By this time, Hagen's public appearances were becoming stranger and frequently included discussions of God, UFOs, her social and political beliefs, animal rights and vivisection, and claims of alien sightings. The English version of Angstlos, Fearless, generated two major club hits in America, "Zarah" (a cover of the Zarah Leander (No. 45 USA) song "Ich weiss, es wird einmal ein Wunder geschehen") and the disco/punk/opera song, "New York New York" (No. 9 USA). During 1984 Hagen spent a lot of time in London and UK based MusicSzene magazine chief-editor Wilfried Rimensberger, in conjunction with Spree Film, produced a first TV feature on her and what was remaining from London's 70 Punk movement induced by artist and model Frankie Stein.
Her 1985 album In Ekstase fared less well, but did generate club hits with "Universal Radio" (No. 39 USA) and a cover of "Spirit In The Sky" and also featured a 1979 recording of her hardcore punk take on Paul Anka's My Way, which had been one of her signature live tunes in previous years. She performed songs from this album during the 1985 version of Rock in Rio. Wilfried Rimensberger and award-winning film director Lothar Spree produced a TV documentary for
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In 1989 she had a relationship with Frank Chevallier from France, with whom she has a son, Otis Chevallier-Hagen.
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In 1998, Hagen became the host of a weekly science fiction show on the British Sci-Fi Channel, in addition to embarking on another tour of Germany. In 1999, she released the devotional album Om Namah Shivay, which was distributed exclusively online and included an unadulterated musical version of the Hare Krishna mantra (in real life she believes that the Hindu incarnation of God known as Krishna was 'the king of Jerusalem'. Krishna is sometimes referred to as "Christ"). She also provided vocals to "Witness" and "Bereit" on KMFDM's Adios.
Also in 1998, she recorded the official club anthem (Eisern Union !) for FC Union Berlin and four versions were issued on a CD single by G.I.B Music and Distribution GmbH.
In 1999, she played the role of Celia Peachum in The Threepenny Opera by Kurt Weill and Bertolt Brecht, alongside Max Raabe. She also regularly performs songs by Kurt Weill, Hans Eisler and Paul Dessau set to Brecht's texts.