Enyeama made his second FIFA World Cup participation in the 2010 tournament in South Africa. In Nigeria's opening match, he was named man of the match, producing a defiant display to restrict Argentina to a 1–0 win. Enyeama, who was playing his 56th international for the Super Eagles, made six fine saves against the two-time world champions, four of them from Lionel Messi. Argentine coach Diego Maradona praised him as the reason Messi was not able to score a goal. Enyeama was also awarded man of the match in the team's next fixture, a 2–1 loss to Greece, but was at fault for Vasilis Torosidis' winning goal.[8]
At the 2013 Africa Cup of Nations, Enyeama deputised for regular captain Joseph Yobo, who stayed on the bench for most of the competition.[6] On 10 February, Enyeama led Nigeria to its third continental victory, keeping a clean sheet in a 1–0 defeat of Burkina Faso in the 2013 Africa Cup of Nations Final. He was named to the team of the tournament as first choice goalkeeper, conceding only four goals in six matches.[9]In June 2014, Enyeama was named in Nigeria's squad for the 2014 FIFA World Cup.[10] In the Super Eagles' first fixture, he kept the second FIFA World Cup clean sheet of his career as the team drew 0–0 with Iran.[11] He subsequently recorded a second consecutive shutout in the fixture against Bosnia and Herzegovina, a 1–0 win which gave Nigeria its first win at the tournament since the 1998 edition.[12] He conceded three goals in the last match of the first round against Argentina, a game which ended in a 3–2 defeat for Nigeria, placing them second in the group and thus qualifying them for the second round for the first time in 16 years.[13]
On 26 March 2015, Enyeama won his 100th cap for Nigeria in a 1–0 loss to Uganda.
