A huckster named Sammy (played by Crystal) travels to Romania on business. After a disappointment, he crashes his car and is rescued while unconscious by an enormous Romanian man named Max (Muresan), close to 8 feet tall.
Once he wakes up and interacts with Max, he sees potential stardom in him. Sammy attempts to broker his introduction into the movies. In doing so he exploits Max's desire to visit a long-lost paramour, Lilliana, in Gallup, New Mexico. First, Max obtains the role of a villain in a movie, but he is so drunk that he vomits on the protagonist. However, the scene is included in the movie.
One day, Sammy talks to Steven Seagal about including Max as a villain in one of his movies, convincing him that he needs a different kind of villain. At first Seagal rejects him because there was another actor who would take that role, but he changes his opinion after listening an extract of a Shakesperian play done by Max.
Suddenly, after some medical exams, Max is diagnosed with heart
disease, which is incurable by a transplant because Max's heart is so
big. Sammy decides to find Lilliana, and tries to convince her to meet
Max again, but she rejects the invitation. Sammy then convinces his wife
to take the role of Lilliana and after some words, Max asks her for a
kiss.Sammy eventually decides to return Max home to Romania. Max refuses to go back, but finally he enters the house and meet his parents again, who abandoned him when he was born. Sammy ends up watching Max's first filmed scene in a cinema with his family.The story was inspired by professional wrestler André the Giant, whom Crystal had met during the filming of The Princess Bride. Steven Seagal appeared as himself.
In an episode of the TV series Friends, Chandler, who is hiding Monica in his suite, uses watching My Giant as an excuse to try to stop Joey from using the hotel room to sleep with a bridesmaid, only to discover that Joey loves the movie and wants to come into the room to watch it. Later in the episode. Joey talks to Chandler about his acting skills compared to the giant's.
In the episode "You May Now Kiss the... Uh... Guy Who Receives" of Family Guy, Lois Griffin visits a priest to help her overcome her fear of gay marriage. After watching a film about homosexuals, the priest suggest they watch My Giant. Lois says "Oh, God no".
