Tsonga followed this up by winning his first ATP Masters Series championship at the 2008 Paris Masters, thus qualifying for the 2008 Tennis Masters Cup in Shanghai, China. His best performances in a major tournament since 2008 are semifinal appearances in the 2010 Australian Open, the 2013 French Open and at Wimbledon in 2011 and 2012. He also reached the final of the 2011 ATP World Tour Finals, where he lost to five-time and defending champion Roger Federer. He achieved his second Masters Series win at the 2014 Canadian Open, defeating four top 10 players on the way to victory.
He is one of the few active players on tour to have reached the quarterfinal stage of all four Grand Slams. He is also one of only two players (the other being Tomáš Berdych) to have Grand Slam wins against each of the Big Four (namely Roger Federer, Rafael Nadal, Novak Djokovic and Andy Murray).